Analysis of cell migration is an important phenotypical assay of processes such as tumor metastasis, immune response and wound healing.

There are four  different types  of cell migration: migration of cells based on a chemical environment (chemotaxis); cell migration within a gradient of chemoattractants (haptotaxis); movement of cells through the vascular endothelium (transmigration), and migration of cells into a wound to close the gap (wound healing).

Most of these assays are compatible with an imaging based readout. Recent strategies have resulted in more advanced cell migration assays that are more accurate, sensitive, convenient and robust, especially in wound healing. 

Oris™ Cell Migration Assay Adherent cell migration assay without the need for transmembrane inserts. Alternative to scratch assay for wound healing studies, Oris™ 96-well Collagen I Coated plates with Oris™ Cell Seeding Stoppers; HT-1080 cell line before (left) and 18 hr after (right) migration into the ‘wound’ area.

Analysis of cell migration is an important phenotypical assay of processes such as tumor metastasis, immune response and wound healing.

There are four  different types  of cell migration: migration of cells based on a chemical environment (chemotaxis); cell migration within a gradient of chemoattractants (haptotaxis); movement of cells through the vascular endothelium (transmigration), and migration of cells into a wound to close the gap (wound healing).

Most of these assays are compatible with an imaging based readout. Recent strategies have resulted in more advanced cell migration assays that are more accurate, sensitive, convenient and robust, especially in wound healing.