LC 300 HPLC and UHPLC Systems

Lamotrigine is an antiepileptic drug in the phenyl triazine class used in the treatment of both epilepsy and as a mood stabilizer for bipolar disorder. It is the first medication since lithium to be granted US FDA approval for maintenance treatment of bipolar type 1, and is approved for use in more ...

The World Health Organization regards omeprazole among its ‘List of Essential Medicines’ which outlines the most effective and safest medicines required by a country's healthcare system to meet its needs. The United States Pharmacopeia (USP) closely monitors the production of these drugs and provide ...

Pregabalin is an anti-epileptic drug that works by slowing down impulses in the brain that cause seizures. It can also be utilized to treat fibromyalgia, or nerve pain in people with diabetes, herpes zoster, or spinal cord injury owing to its ability to affect chemicals in the brain that send pain s ...

This Application Brief demonstrates the ability of PerkinElmer's LC 300 instrument platform, and SimplicityChrom™ chromatographic data system (CDS) software to successfully meet the United States Pharmacopeia (USP) performance requirements for the HPLC analysis of Triamcinolone Acetonide purity. ...

This Application Brief demonstrates the ability of PerkinElmer's LC 300 instrument platform, and SimplicityChrom™ chromatographic data system (CDS) software to successfully meet the United States Pharmacopeia (USP) performance requirements for the HPLC analysis of Risperidone impurities. ...

Risperidone is an antipsychotic medicine that works by changing the effects of chemicals in the brain. The methods for assessing Risperidone characteristics are described in the United States Pharmacopeia and rely on chromatographic techniques. In this application brief, we demonstrate the suitabili ...

This Application Brief demonstrates the ability of PerkinElmer's LC 300 instrument platform, and SimplicityChrom™ chromatographic data system (CDS) software to successfully meet the United States Pharmacopeia (USP) performance requirements for the HPLC analysis of Triamcinolone Acetonide. ...

This application note describes a regulatory LC/MS/MS method for the qualitative identification of tortoise-shell glue, an important Traditional Chinese Medicine (TCM) known for its hemopoietic and hemostatic properties.

This application note outlines an LC-UV method for analyzing oleanolic acid and ursonic acid in Chaenomelis fructus, known for its medicinal properties.

This application note discusses a qualitative LC/MS/MS workflow for identifying donkey-hide gelatin, a valuable traditional Chinese medicinal product.

Accurate identification and quantification of cannabinoid content is a critical step in the process to bringing safe and high quality cannabis flower and fortified products to market. As the legalization of recreational cannabis use continues throughout the world, fast and efficient liquid chromatog ...

Parabens are utilized as an antimicrobial preservative in many commercial offerings including cosmetics, personal care products and foods, and offer both chemical and thermal stability to products. Although parabens increase the safety of products, recent studies have suggested that parabens may exh ...

Isoflavones are water-soluble compounds found in many plant and food sources. Designated as phytoestrogens, isoflavones are structurally similar to to the female hormone estrogen, and have been shown to exhibit a number of beneficial impacts to human health, such as a reduction in the development of ...

High fructose corn syrup (HFCS) as a substitute for sucrose in a wide variety of products, including baked goods, sauces, beverages, canned fruits and dairy products. HFCS is produced from regular corn syrup, with an enzymatic process that isomerizes some of the corn syrup's glucose into fructose. T ...

Maple syrup, a common natural sweetener, is consumed regularly by households around the world. Quantification of sugar content in maple syrup is paramount to satisfy product labeling requirements and ensure label-claim accuracy. Although sucrose is the primary sugar component in maple syrup, a compl ...

Acrylate polymers are utilized for a host of applications due to their varied physical properties and ease of synthesis. These acrylates are sought after specifically for coatings, adhesives, sealants and elastomers (CASE) applications because of their stability, high heat resistance, excellent weat ...

The recent emergence of mRNA-based vaccines and therapies has made clear the need for reliable analytical methods that can successfully identify, characterize, and quantify mRNA. This chemical instability demands a deeper understanding of the mechanisms by which mRNA degrades, which can inform the d ...

Vitamins are involved in a variety of different physiological processes and must be assimilated with the daily nutrition as they cannot be synthesized within the human body. The biochemical functions of vitamin C (ascorbic acid) are mainly linked to its antioxidant and radical scavenger properties. ...

This application note demonstrates a method for the routine sample preparation and quantitative determination of lactose in mozzarella and ricotta cheeses and milk. As the monosaccharaides glucose and galactose can be hydrolytically or enzymatically produced from lactose, these two sugars were also ...

This application note presents a detailed LC-UV workflow for analyzing glutaraldehyde in bioprosthetic heart valves using the PerkinElmer LC 300 system.

This application note describes the quantification of paeoniflorin in Paeoniae radix alba using a PerkinElmer LC 300 UHPLC system. By employing a polar column, the method enhances separation performance and meets the Chinese Pharmacopoeia specifications.

This document details a rapid LC/MS/MS workflow for analyzing gelatinous traditional Chinese medicines using the PerkinElmer QSight LX50 UHPLC system.

This application note presents a sensitive LC/MS/MS method for detecting aflatoxins in Coix seed, a traditional Chinese medicine. The analysis, conducted on a PerkinElmer LC 300 system, meets the stringent sensitivity and accuracy requirements of the Chi

This application brief details a comprehensive LC-UV method for analyzing multiple characteristic components in Lonicerae japonica flos, used for treating inflammation and infectious diseases.

This application note presents an LC-UV workflow for the quantification of chlorogenic acid in children's throat-reliever granules, a traditional Chinese medicine. The analysis was conducted using a PerkinElmer LC 300 UHPLC system with a C18 column.

This document outlines a robust LC-UV method for quantifying the triterpene acids oleanolic acid and ursonic acid in Eriobotrya japonica leaf, a traditional Chinese medicinal material. Utilizing a PerkinElmer LC 300 system with a C18 column, the method a

This application note describes a detailed LC-UV workflow for analyzing ferulic acid, an important phenolic acid used for quality assessment, in Angelica sinensis (A. sinensis). The analysis was performed using a PerkinElmer LC 300 system equipped with a

Best Practices for HPLC to UHPLC Method Transfer Converting a method from HPLC to UHPLC has a number of benefits, as outlined in the first 2 articles in our series, including faster analytical separations, better peak resolution and lower long-term costs

Monitoring the consistency and quality in soft drinks is essential to ensure a positive brand image and a loyal customer base. Our full portfolio of chromatography solutions, including LC, GC and GC/MS, enables you to meet – and even exceed – your quality control goals with rapid, intuitive, and acc ...

For laboratories looking to achieve the highest levels of versatility without compromising on productivity, the LC 300 HPLC and UHPLC Systems deliver the flexibility, performance, and efficiency you need for even the most challenging analytical demands. With fully customizable configurations and acc ...

Download this interactive brochure to see all our biofuel lab solutions and supporting services. Maximize your laboratory's prospects in biofuels production and testing with PerkinElmer’s analytical solutions that can help you achieve high product qualit

Download this Flyer for an overview of PerkinElmer's analytical solutions for the Semiconductor industry. This 2-page flyer outlines semiconductor and microelectronic workflows and applications, and the precise and reliable PerkinElmer solutions to address them - including instrumentation, consumabl ...

SimplicityChrom™ is a modern, intuitive and flexible CDS software platform that enables users to efficiently control their instrument, process data, and generate results. Pair this functionality with the peace of mind of 21 CFR Part 11 compliance and industry-leading service and support, and you’re ...

There are many characteristics to consider when choosing a detector, therefore several detectors have been developed over time to address particular challenges. It is important to consider the chemical nature of the analytes of interest and any potential interferences, when choosing a detector. Addi ...

For laboratories looking to achieve the highest levels of versatility without compromising on productivity, the LC 300 HPLC and UHPLC Systems deliver the flexibility, performance, and efficiency you need for even the most challenging analytical demands. With fully customizable configurations and acc ...

The injection of an accurate and reproducible sample volume into a UHPLC system is challenging, but essential to ensuring a high quality analysis. The patented PerkinElmer Intermediate Loop Decompression (ILD) valve, featured in the LC 300 Autosampler, is a 7-port valve with a strategically placed r ...

For laboratories focused on achieving high levels of efficiency, without compromise on productivity, the PerkinElmer LC 300 HPLC and UHPLC System offers performance and productivity even for the most challenging analytical demands. Discover more.

The foundation of great Chromatography starts with selecting the right column. Our LC column portfolio brings you new opportunities for full performance-boosting LC workflow solutions, ensuring that you have the optimum column for your application.

This presentation is the first in a series that will introduce you to the highly useful analytical technique - High Performance Liquid Chromatography - Mass Spectrometry (LC-MS).

Watch our on-demand webinar to discover the difference that a focus on improving the user experience will have on your workflows and productivity.