Infrared Spectroscopy has become a ubiquitous tool in the analysis of pharmaceutical raw materials, with both Mid- and Near-infrared spectroscopy functioning as commonplace techniques for the investigation of both excipients and active pharmaceutical ingredients (APIs). Near-infrared spectroscopy is arguably the most common spectroscopic technique for the interrogation of incoming raw materials. Mid-infrared spectroscopy generally contains the most information regarding the chemical structure of an analyte, making it particularly useful for identification and analysis of active materials in pharmaceutical samples. This application note describes how the PerkinElmer Spectrum 3 FT-IR spectrometer together with the 21 CFR part 11 compliant Spectrum 10 software provides a high-performance solution for mid and near infrared analysis of materials used in the pharmaceutical industry.